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KMID : 0387719940050020137
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Korean Journal of Blood Transfusion
1994 Volume.5 No. 2 p.137 ~ p.141
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The Effect of Additional Factor XIII on Cross-Linking in Fibrin Glue
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Abstract
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To investigate the effect of additional factor XIII on the rate of cross-linked fibrin formation in fibrin glue, we prepared concentrated fibrinogen as a source of fibrin glue using thawsyphon method from fresh frozen plasma, purified human
factor
XIII
from plasma, and performed biochemical analysis of the fibrin glue formed with or without additional factor XIII. It was concluded that additional factor XIII promoted rapid formation of cross-linked fibrin (γ-γ dimer and α-polymer) which
would
be
essential to clinically effective fibrin glue.
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